Correlation between mean lung density and lung function test in patients with chronic obstructive pulmonary disease by dual phase CT / 西安交通大学学报(医学版)

ABSTRACT: Objective: To investigate the correlation between the biphasic mean lung density (MLD) measured by a computer-aided method and the pulmonary function test (PFT) in patients with chronic obstructive pulmonary disease (COPD). Methods: Sixty COPD patients diagnosed in The Affiliated Hospital of Yan'an University from June 2017 to June 2018 were retrospectively recruited. CT scans at the end of inspiratory phase and the end of expiratory phase were performed. MLD of the whole lung and individual lobes were measured by a three-dimensional method, and PFT was performed within one week. The correlation between MLD and PFT was analyzed. Results: We found a slight positive correlation between MLDin and PFT of the whole lung and each lung lobe (P<0.05). MLDex, MLDex-MLDin of the whole lung and each lung lobe showed moderate to high positive correlation with PFT (P<0.01), and MLDex/in of the whole lung and each lung lobe showed moderate to high negtive correlation with PFT (P<0.01). Conclusion: Quantitative measurement of mean lung density in COPD patients is correlated with lung function and MLDex/in of the whole lung shows the highest correlation.

Changing curve of mean lung density of normal preschool children based on computer assisted measurement / 实用放射学杂志

Objective To investigate the changing curve of mean lung density (MLD)in normal preschool children based on CT quantitative measurement.Methods Chest CT data of 409 preschool children were reviewed retrospectively from the "digital lung"database.A computerized algorithm based on the "digital lung"was applied to all examinations in a batch manner.The MLD values of total lung,right lung,left lung and each lobe were obtained automatically.Results There was no correlation between the gender and MLD,however a moderately negative correlation was found between the age of month and MLD (P＜0.05).No significant difference of MLD was found between genders of the same age of month group,except in left lower lobe of 49-60 months of age (P=0.043). The MLD was decreased gradually with age (P＜0.05).Conclusion There is not a statistical difference in MLD between the preschool boys and preschool girls of the same age of month.With the growth of preschool children,the MLD is gradually decreased.